1382: Inhibition of Serum and Glucocorticoid-responsive kinase-1 (SGK1) in Heart Disease and Cancer

Small molecule inhibitors of serum and glucocorticoid regulated kinase-1 (SGK1) were identified using computer aided drug discovery and derivatives created and discovered to have potential for the treatment of cardiac arrhythmias. The mechanism of action was found to involve modulation of sodium flux in the heart. Catherine Lenich clenich@bidmc.harvard.edu 617-667-0568

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