2015-126 – Mesoporous Silica Nanoparticles and Supported Lipid Bilayer Nanoparticles for Biomedical Applications

Background Targeted nanoparticle-based drug delivery systems hold the promise of precise administration of therapeutic cargos to specific sites, sparing collateral damage to non-targeted cells/tissues and potentially overcoming multiple drug resistance mechanisms. However, successful development of such targeted nanocarriers has proven to be a complicated task. An effective targeted nanocarrier forin vivoapplications would include: 1) uniform and controllable particle size and shape; 2) high colloidal stability under physiological and storage conditions; 3) minimal non-specific binding interactions, uptake by the mononuclear phagocyte system (MPS), or removal by excretory systems, allowing extended circulation time; 4) high specificity to abnormal cells or tissues; 5) noninvasive imaging and diagnosis; 6) high capacity for and precise release of diverse therapeutic cargos; and 7) low immunogenicity and cytotoxicity. Dramatic advances have been made in the last decade in developing multifunctional nanocarriers. The progressive techniques have included surface and charge modification, development of hybrid material chemistries, incorporation of functional machines such as stimuli-responsive agents, and conjugation with targeting ligands. However, few nanocarrier platforms exhibit the combined desirable characteristics enumerated above. Thus, there is a market need for a novel method allowing simultaneous attainment and optimization of neededin vivocharacteristics. Technology Description Researchers at the University of New Mexico have developed a novel synthesis method of producing monosized protocells from monosized mesoporous silica nanoparticles (mMSNPs). The protocells are controlled for overall size and shape, pore structure and size, surface chemistry, and targeting. The controllable factors allow for maintenance of particle size monodispersity andin vivostability. In addition, exhibition of colloidal and storage stabilities in aqueous solutions (water, buffer, blood, plasma, etc.) results in the protocells’ ability to maintain their monodispersity for extended periods of time. Consequently, the protocells can be integrated into uni- or multilamellar vaccines to supply immunogenic response inducing factors to a desired target. Gregg Banninger GBanninger@innovations.unm.edu 505-272-7908

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