2016-004 – Antigens for Vaccine Against ETEC-related Diarrhea

Researchers at Kansas State University have developed a structure-based multiepitope fusionantigen (MEFA) technology for vaccines against Enterotoxigenic Escherichia coli (ETEC) bacteria.The MEFA technology uses a backbone protein to present multiple heterogeneous epitopes fromthe adhesin tips of different ETEC bacteria. This antigen, referred to as the “tip MEFA”, works byinducing antibodies that prevent various bacteria from adhering to host cells. As a result, this tipMEFA peptide can be used for developing broad-spectrum vaccines against ETEC-associatedchildren’s diarrhea and travelers’ diarrhea. Aarushi Gupta-Sheth aarushi@ksu.edu 785-532-3907