2017-050 – PRRSV Resistant Pigs

Researchers at Kansas State University have discovered small mutations in the CD163 gene of pigs that confers resistance to porcine reproductive and respiratory syndrome virus (PRRSV) without disrupting the beneficial functions of CD163. Other research teams have shown thecomplete knockout of CD163 confers complete resistance to PRRSV infection. Since CD163 is important for maintainingseveral homeostatic processes, such as scavenging excess hemoglobin andregulating inflammation after tissue damage, the complete loss of CD163 comesat a price. K-State’s research discovery will allowswine genetic companies to develop pigs that are resistant to PRRSV withoutcreating potentially new health issues from completely knocking out the CD163gene. Bret Ford bretford@ksu.edu 785-532-3924

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