ZEBRAFISH MODELS FOR DRUG DISCOVERY AND GENETIC EPILEPSIES

Using CRISPR/Cas9 gene editing or ENU-based mutagenesis, researchers at UCSF have created stable transgenic Zebrafish models representing genetic mutations found in children with catastrophic childhood epilepsies and/or autism spectrum disorders with epilepsy. Zebrafish models have been generated and characterized for four genes, with an additional fish under development. To date, over 1300 drugs have been […]

VACUUM ACTUATED SURGICAL RETRACTORS

Retraction of tissues or organs during surgical procedures can be complicated by trauma or damage to the tissue as a result of the rigid or sharp devices used in the process. This can result in complications such as bleeding or other fluid and tissue leakage. In order to address this concern, inventors at UCSF have […]

USE OF STREPTOCOCCUS THERMOPHILUS lacZ AS A VERSATILE REPORTER GENE FOR CANDIDA ALBICANS

The beta-galactosidase-encoding gene from E. coli, lacZ, has proved to be a highly versatile reporter of gene expression in the yeast Saccharomyces cerevisiae, having been used to study many aspects of signal transduction pathways, gene regulation and other cellular processes. However, the expression of this and other reporter genes in the human pathogen, Candida albicans, […]

Use of Novel Target to Inhibit Nucleotide Synthesis in Cancerous Cells

Investigators at the University of California, San Francisco have identified a target which can be utilized for inhibition of the nucleotide biosynthetic pathway.  This target is a key component for the production of pyrimidines, purines and pyridines.  Since it is specific to proliferating cells, inhibition of this target may effectively avoid toxicity in normal cells while […]

Use of Embryonic Stem Cell-Specific microRNAs to Safely Promote Induced Pluripotency

Scientists at UCSF have discovered a family of novel microRNAs that enhance pluripotency in somatic cells by replacing the activity of Myc, one of the currently required reprogramming factors. Because these microRNAs do not self-replicate, they offer a safer alternative in the generation of induced pluripotent cells as cell therapeutics and research tools. Novel use […]

UCSF Chimera: Molecular Modeling Software for Visualization and Analysis of Molecular Structures

UCSF Chimera offers 3-D visualization of molecular structures and related data, including density maps, supramolecular assemblies, molecular dynamics trajectories, and multiple sequence alignments. The user can also create images and animations for publication and presentation. Besides supporting core visualization, the software is specifically designed for extensibility, to allow outside developers to incorporate new desirable functions. […]

Two-Dimensional Deformable Phantom, A Device For Quantitatively Verifying Deformation Algorithms

As interventional radiology has become more widespread and diverse in its application, a major need has emerged for improved methods to accurately model the distortions to tissue that occur both within a single treatment session (e.g. during injection of therapeutic agents or catheter insertion during brachytherapy) and across longer time frames (e.g. tracking tumor dynamics […]

Tunnel Junction Devices with Optically-Pumped III-Nitride Layers

Researchers at the University of California, Santa Barbara have developed a method of replacing standard electrical injection of the quantum wells in semiconductor devices with optically-pumping, by coupling a short-wavelength electrically pumped active region to a long-wavelength optically pumped region via a tunnel junction. Optically pumping allows for the creation of multiple quantum wells, thereby […]