2018-233 Antibacterial and Instant Clot Forming Wound Dressing

This new invention describes a wound dressing that was made by integrating therapeutic agents, which were made by combining SNAP, propolis, and TXA, into a base polymer made up of Carbosil. Both the wound-facing and the environment-facing sides of the dressing have been engineered for different purposes. The wound-facing side is designed to promote the formation of blood clots within 10 minutes by using a resinous matrix and an antifibrinolytic agent. While the wound-facing side of the dressing promotes clot formation, the environment-facing side of the dressing also helps prevent infection by using an antimicrobial effective amount of nitric oxide (NO) donors. In addition, the dressing avoids being cytotoxic by including biocompatible material. The dressing’s instant clot formation was validated when tested in a 15 minute study with porcine whole blood and platelet extract in vitro. The antibacterial properties of the dressing resulted in a 99.3% reduction in Acinetobacter baumannii, which is one of the most common bacteria associated with wounds. Additionally, when tested on smooth muscle cells and mouse fibroblast cells in vitro, the dressing showed no cytotoxic response after 24 hours of exposure. Cheryl Junker JunkerCL@uga.edu 706.542.4216