Prediction Tools for Vedolizumab Drug Exposure and Efficacy for Ulcerative Colitis and Crohn’s disease

Vedolizumab (VDZ) is an effective therapy for the management of patients with moderately to severely active ulcerative colitis (UC) or Crohn’s disease (CD) who have failed conventional therapy with aminosalicylates, corticosteroids, and thiopurines, as well as biologic therapy with tumor necrosis factor (TNF) antagonists. Several studies have identified potential predictors of treatment outcomes; however, the […]

Prediction Tools for Vedolizumab Drug Exposure and Efficacy for Ulcerative Colitis and Crohn’s disease

Researchers at UC San Diego have addressed this gap by deriving multivariable logistic regression prediction models and clinical design support tools (CDST) using the GEMINI clinical trial data sets for the outcomes of corticosteroid-free clinical and endoscopic remission. The correlation between variability in VDZ exposure and differences in efficacy across predicted probability groups was explored […]