2020-051 – Discovery, Synthesis and Development of Novel Antibacterial Compound and its Derivatives for Dental Caries and Other Bacterial Diseases

Streptococcal mutans inhabits the mouth andcontributes to tooth decay (dental caries). Despite the implementation ofmeasures to control and treat dental caries with fluoride, chlorhexidine, andtheir associations, it remains the most prevalent dental disease in manycountries. Dental caries is a multifactorial infectious disease caused by the accumulationof biofilm on the surface of teeth. S. mutans is considered the mostcariogenic of all oral streptococci and the primary causative agent of dentalcaries. This bacterium is responsible for the development andprogression of oral caries lesions andcan cause other systemic diseases. S. mutans can also attach toother oral pathogens and augment oral diseases. Researchers at Kansas Statehave identified a small molecule with antibacterial and antibiofilm activityagainst S. mutans. This compound isnontoxic to mammalian cells. It was found to contain antibacterial andantibiofilm activity at varying concentrations against S. mutans, andother Gram-positive bacterial pathogens including Methicillin-resistant Staphylococcusaureus (MRSA). Streptococcal and Staphylococcal bacterial pathogens arenumber one and number two leading nosocomial bacterial pathogens, respectively,and difficult to treat because of their frequent encounter with humans andtheir inherent antibiotic drug resistance. Caronda Moore caronda@ksu.edu 785-532-1366

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