Validation of specimen self-collection vs. collection by health care worker for COVID-19 testing (Andra Blomkalns, Jonathan Altamirano, Prasanthi Govindarajan, Yvonne Maldonado)

Maldonado, Altamirano, Govindarajan and Blomkalns are investigating three swab techniques used during COVID-19 testing: a self-collected nasal swab performed with the aid of an instruction sheet; a health care worker-collected nasal swab; and a health care worker-collected oropharyngeal swab. Should self-collected nasal swabs prove as effective as those collected by health care workers, patients may […]

Using human organoids to understand COVID-19 infection (Calvin Kuo, Catherine Blish, Manuel Amieva)

Kuo, Amieva and Blish are recreating the SARS-CoV-2 infection in three-dimensional human mini-organs, or “organoids.” SARS-CoV-2 is the virus that causes COVID-19. Kuo and Amieva are investigating details behind how the virus infects human lung and intestinal tissues through organoid models, and Blish is studying the response of individual cells infected with SARS-CoV-2. Stanford Office […]

Using artificial intelligence to predict drugs that may inhibit COVID-19 (Russ Altman)

Altman and his group have used artificial intelligence to computationally predict six drugs that could inhibit TMPRSS2, a protein that plays a key role in SARS-CoV-2 infections. Altman and his collaborators outside of Stanford Medicine plan to conduct experimental follow-up studies to explore the efficacy of two of the drugs in blocking SARS-CoV-2 from causing […]

Ultra-strong Aluminum Alloy Formulation with Superior Thermal Stability at High Temperatures

Technology Readiness Level: Process Validation in Lab Researchers at Purdue University have developed an ultra-strong aluminum alloy with superior thermal stability at high temperatures. This alloy demonstrates superb microstructural and mechanical stabilities up to 400˚C, 72 percent of aluminum’s melting temperature. Conventional aluminum alloys have yield strength values limited to around 700 MPa and operation […]

UGA Research on COVID 19

Creating treatments. Everyone desperately wants an effective treatment for COVID-19, but no large-scale study has yet proven any drug or drug combination effective at fighting off the virus. There’s also no vaccine to prevent infection. UGA researchers are part of a massive effort to change that.Scott Pegan, director of the Center for Drug Discovery in […]

Tracking COVID-19 with wearables (Michael Snyder)

Snyder and his team will track biological parameters of individuals who are ill with COVID-19 or at risk for the disease using a smart watch. Their goal is to determine whether they can tell if the smart watch user is becoming ill based on measurements such as heart rate. Stanford Office of Technology Licensing […]

Systems biological “multi-omics” analysis of immunity to COVID-19 infection (Bali Pulendran)

Pulendran is investigating the interaction between the human immune system and the SARS-CoV-2 virus through systems-biological methods. His group will use a “multi-omics” approach to probe the host immune system response to SARS-CoV-2 during asymptomatic and symptomatic phases of infection. Their goal is to determine why some people get more severe symptoms than others and […]

Stanford Coronavirus Study to understand behavioral and societal impacts (Eleni Linos)

Linos and her team are developing a website with reliable public health information about COVID-19 and surveys about the social and behavioral impact of the evolving pandemic. They also plan to share survey results to directly inform public health practitioners, health care systems, clinicians and policymakers about the informational, social and health needs of community […]

Specimen collection during COVID-19 clinical trials and lab biosafety enhancements (Angela Rogers, Aruna Subramanian, Catherine Blish, Philip Grant)

Subramanian and Grant are co-principal investigators of a Gilead-sponsored clinical trial that evaluates the safety and efficacy of using the Ebola drug remdesivir to treat patients with COVID-19. In parallel with these trials, Blish wants to collect specimens, such as blood and stool samples, and later expand collection to individuals outside of the trials. These […]