Ultra-High Sensitivity RT-PCR for Viral Genome Sequencing (UA16-197)

This technology is a process for genome sequencing of RDA-DNA fragments found in archived or damaged biological samples. The process utilizes large panels of primers to amplify short RNA-DNA fragments into separate and off-set pools. These off-set pools of amplicons are used to reconstruct whole and near-whole genomic sequences in samples otherwise deemed non-useful. This […]

UIC-2019-103 Method of Use of Mitogen Activated Protein Kinase Kinase (MEK) Inhibitors

Use of Mitogen Activated Protein Kinase Kinase (MEK) inhibitors to treat congenital aniridia: Improves ocular morphology and development. Reduces corneal stromal thickness, scar area, and opacity. Increases ocular function and response to light stimulation. Observed via electroretinography. Effective in both oral and topical formulations. Preliminary evidence indicates that the formulated MEK inhibitor is soluble in […]

UIC 2018-074 and UIC 2020-020- Novel peptides inhibiting cell-cell aggregation and vascular occlusion in thromboinflammatory diseases

Platelet-released PDI promotes the ligand-binding function of glycoprotein Ibα (GPIbα) and induces platelet-neutrophil interactions and vascular occlusion in thromboinflammatory conditions. Extracellular PDI is crucial for platelet thrombus formation in arterial thrombosis and neutrophil recruitment in vascular inflammation. However, the development of specific PDI inhibitors is challenging because of their selectivity over 21 PDI family member […]

Natural Treatment for Ventilation Induced Lung Injury (UA16-075)

This invention is the use of bixin, a NRF2 inducer, to reduce the lung damage caused by mechanical ventilation. Bixin was found to suppress inflammatory mediators, reduce alveolar capillary leakage, and protect against DNA oxidative damage. This can be used to treat ventilator-related lung damage in patients with COVID-19.Background:Mechanical ventilation is used to assist patients […]

Microcavity Surface Bioconjugation Using Unilamellar Lipid Membranes for Label-Free and Ultrasensitive Detection (UA19-073)

This invention is a new surface smoothing method for microtoroid optical resonators, resulting in ultrasensitive detection and reduced scattering loss when looking for key biomarkers in medical imaging. This new method produces higher Q-factors and reduces scattering loss, which is important when detecting key biomarkers such as amyloid-_. This has potential application in biomarker detection […]

Label-Free Single Molecule Spectroscopy and Detection (UA18-063)

This invention incorporates FLOWER (a label-free, patented biological and chemical sensing system) with dual-frequency comb spectroscopy for molecular detection andidentification. The inventors have improved the signal-to-noise ratio of these measurements more than 1,000 times using frequency locking feedback control in combination with innovative data processing techniques. This optical technology has remote sensing capabilities that can […]

Interfacial Effects Enable Droplet Actuation, Inhibition Relief, and Early Sensing of Polymerase Chain Reaction (UA15-071)

This technology is a device and associated methods that improve quantitative real-time polymerase chain reaction (qPCR) by allowing detection of PCR amplification and quantification of initial target amount to occur at an earlier amplification cycle. This innovation is possible through the novel utilization of interfacial effects in PCR reaction droplets. Ultimately this allows for faster […]

Epidemic Predictive Model (EpiGro) (UA16-052)

This software models and predicts epidemics in Pan American Health Organization (PAHO) countries using Chikungunya and dengue incidence. It has an easy-to-usegraphical user interface (GUI), and can be used to monitor COVID-19. The open source software download is availableat https://bit.ly/TLA-EpiGro.Background:This software uses a mathematic model based on the 2014-2015 Chikungunya epidemic, which allows users to […]

eHIP – the eHealth & Intervention Platform (UA16-123)

Inventors from the University of Arizona Bio Computing Facility have developed eHIP (eHealth & Intervention Platform), a platform for conducting mobile device-basedhealth interventions and behavioral research. This platform includes text, voice, and video messaging systems, data collection, and web-based forms. These features can be modified, or built from scratch to suit the specific needs of […]