Zika Virus Sensor – IP 1628

Zika virus, a mosquito-bornepathogen, has been linked to occurrences of microcephaly when the virus ispassed from a pregnant woman to her fetus. Currently, enzyme-linkedimmunosorbent assay (ELISA) and real time-polymerase chain reaction (RT-PCR)are two major laboratory methods available for detecting Zika virus (ZIKV).These methods can be used to detect the virus, for example, within 3-10 days […]

Wireless Implantable Pressure Monitor for Internal Organs

A “Fitbit” for the bladder. The UroMonitor is the first wireless, catheter-free bladder monitoring device designed to be inserted and extracted trans-urethrally, and transmits functional data during activities of daily living with improved diagnostic relevance, increased patient comfort, and without the need for a specialized urodynamics expert. Any patient suffering from incontinence, including stress urinary […]

The Laser Otoscope

An otoscope that uses a highly focused light source, such as LED, laser, laser diodes, etc. to identify the presence of fluid behind the tympanic membrane given the reflectance pattern. The Laser Otoscope provides much higher accuracy readings than conventional otoscopes, while using low power and safe laser light sources. •Issued U.S. patents •Prototype built […]

Structure-switching aptamers and sensors for detection of synthetic cathinones – IP 1849

Syntheticcathinones (also known as bath salts) are designer drugs sharing a similar corestructure with amphetamines and 3, 4-methylenedioxy-methamphetamine (MDMA). Theyare highly addictive central nervous system stimulants, and are associated withmany negative health consequences, including even death. Although these drugshave emerged only recently, abuse of bath salts has become a threat to publichealth and safety due […]

Sprayer to Prevent Thrombosis

A device that increases blood flow to the left atrial appendage via a “sprayer”. This sprayer is a tube that begins in the left appendage and directs a portion of the blood flow directly into the left atrial appendage. Concept only Torey Hovest hovestt@ccf.org 216-445-5431

Silica Materials for Chromatography and Extraction – IP 1652

Currently available bonded phasesused in HPLC, UPLC and SPE employ silica particles as the base material. Toincrease the phases applicability and adaptability, the surface of theparticles can further be modified by bonding a wide variety of functional groupsto the surface: non-polar (e.g. C18), polar (e.g. NH2), ionic (e.g.propylsulphonic acid) or mixed-mode (e.g. C8/cation exchange). However, […]

Particulate Sorbents and Method of Preparation – IP 1748

Traditionally, a large numberof particulate matters are used individually or in different combination asadsorbents in water filtration system, air pollutant trapping systems, sewagetreatments plants, to name a few. Many of these particulate matters possessextremely high surface area, but disadvantageously demonstrate a strongtendency to form agglomeration, therefore excluding a large portion of theseparticles’ available surface area […]

Novel Assay and Peptide Inhibition of the CALPAIN-5 (CAPN5) Enzyme

These CAPN5-inhibitor peptides could be developed into biologics for treating ADNIV Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy (ADNIV) is an inherited disease characterized by retinal and iris neovascularization, abnormal retinal pigmentation, anterior chamber and vitreous inflammation, cystoid macular edema; vitreous hemorrhage, and traction retinal detachment. Mutations in the CAPN5 gene cause ADNIV. CAPN5 is the first […]

Native Valve Annulus with Ring and Prosthetic Valve

The present invention relates to an endoluminally-delivered aortic prosthetic valve. A padded ring is placed in the aortic valve annulus and pushes outward against the valve annulus. The ring stays in place through outward compression against the native valve annulus. A prosthetic valve is placed inside the ring and deployed to push outward against the […]

Nanoformulations for Treating HIV-Associated Neurocognitive Disorders – IP 1656

With proper medications humanimmunodeficiency virus (HIV) patients now live almost full lifespans; however, HANDcontinues and its prevalence is increasing. This may be, in part, because HIVinfection remains in the brain. Anti-retroviral therapies (ARV)have been shown to improve cognition and reduce the prevalence ofHIV-associated dementia; however, continued HIV infection and aging processexacerbate the incidence of HAND. […]