UMIP-67 – A Novel Anti-Angiogenic Therapy for Neovascular Diseases

Problem Proliferativeretinopathies, such as diabetic retinopathy (DR) and retinopathy of prematurity(ROP), are attributed to the abnormal proliferation of vasculature within theretina; the abnormal vasculature also lacks the architecture and structuralintegrity of normal vasculature. DRaffects approximately 8 million individuals in the United States, with 80% ofpatients with a 20+ year history of diabetes being afflicted. About […]

UMIP-60 – Large Scale Production of Purified Schwann Cells From Nerve Tissue For Clinical Use

Problem:Within the field of regenerative medicine, the application of transplantation to repair injuries and to treat disease is accelerating. In terms of commercially developed cellular therapeutics, the majority of FDA-approved products, such as umbilical cord blood derived hematopoietic stem cells, are for hematological diseases. It is urgent that regenerative medicine be applied to injuries and […]

UMIP-326 – Isothermal Point of Care Method for Detection of Human Papilloma Virus (HPV)

Problem: According to the US Centers for Disease Control, “Human Papilloma Virus (HPV) is the most common sexuallytransmitted infection, affecting nearly 80 million people in the US alone, inmost cases, people are infected in their late teens and early 20s, are infectedwith HPV. There are many different types of HPV, many are harmless, but sometypes […]

UMIP-249 – A Unique Form of Herpesvirus Vector

Problem: Human immunodeficiency virus (HIV) is able to replicate continuously without relent despite apparently strong humoral and cellular immune responses to the virus. The HIV envelope glycoprotein is shielded with a large amount of carbohydrate and the trimer spike as it exists of the surface of virions is difficult for antibodies to access and difficult […]

System and Methods for Decoding Neural and/or Electromyographic signals – IP 1311

FIU inventorsare designing and developing a system that will enhance the level offunctioning provided by prosthetic limbs. Commercially available prosthesesemploy electromyogram (EMG) signals recorded from muscle tissues in residuallimbs in order to infer motor intent of the user. Continuingresearch and development has shown that peripheral nerve activity of humanamputees can serve as an alternative to […]

Surface Plasmon Resonance Biosensor for Real-time Measurements from Living Cells – IP 1228

Previouslyestablished SPR based sensing platforms have been limited to detection ofanalytes in a prepared sample. This requires collection of analytes from thecell culture media, purification, and pretreatment of analytes for the purposeof cellular exocytosis and cellular signaling pathway studies. These redundantsteps are time consuming, and also introduce unpredictable errors to theexperiments. Among all types of […]

Organometallic Nitric Oxide Fluorescent Sensor – IP 1205

Nitric oxide (NO) is an endogenously produced molecule thatplays critical roles in numerous physiological processes. Dysregulation ofNO-dependent signaling has been associated with numerous pathologicalconditions, and medical interventions already exist that target the NO pathway.Our understanding of the roles of NO in the human body is hindered by thedifficulty of assessing NO levels in biological tissues. […]

Novel Azulenyl Nitrone Spin Trapping Agents – IP 1101

Spin trapping agents have been widely used for freed radicalresearch and therapeutic applications. The superoxide radical is considered toplay important roles in physiological processes as well as in the genesis ofdiverse cytotoxic conditions such as cancer, various cardiovascular disordersand neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS),Parkinson’s disease (PD) and Alzheimer’s Disease (AD). The detection […]

Microstructurally Engineered Perovskite Gas Sensors

Technology has been validated by in-lab testing. Researchers at Purdue University have fine-tuned a new class of ReNiO3 based perovskite sensors for hydrogen gas (H2) detection. The sensors operate at a significantly higher sensitivity as compared to the current technologies. Traditional Hydrogen gas sensors have only been used so far in applications such as alarm […]