202107 – Repurposing Chlorzoxazone to Treat Schizophrenia Symptoms

Schizophrenia affects more than 20 million people worldwide, with approximately 3.5 million people diagnosed with schizophrenia in the United States. The condition is characterized by various symptoms that affect mental state, emotions, behaviors, and cognition. While antipsychotics are widely used to treat schizophrenia, most have limited therapeutic efficacy. Hence, there is an unmet need to develop new treatments. Researchers at FAU propose repurposing an FDA-approved drug, chlorzoxazone (CZX), which can activate small conductance calcium-activated potassium (SK) ion channels and may be a promising therapeutic to treat attention and memory deficits associated with schizophrenia. Preclinical animal studies of schizophrenia show CZX significantly reduced memory deficits. Hence, CZX could be a promising treatment of cognitive symptoms in schizophrenic patients. FAU is seeking partners to advance this technology into the marketplace through licensing or development partnerships. Dana Vouglitois dvouglitois@fau.edu 561-297-0673

Related Blog

Smart, interactive desk

Get ready to take your space management game to the next level with the University of Glasgow’s innovative project! By combining the

Mechanical Hamstring™

University of Delaware Technology Overview This device was created to allow athletes who suffer a hamstring strain to return to the field

Join Our Newsletter

                                                   Receive Innovation Updates, New Listing Highlights And More