CeLLife: Safe Second-life Batteries

Tampere University Background CeLLife answers the problem of the growing amount of e-waste from rechargeable lithium-ion batteries. Currently used batteries become a burden for their owner when they need to be recycled. Batteries are crushed and material is recovered. A lot of work and energy is wasted in this manner, because up to 90 percent […]

Humanized Monoclonal Antibodies and Chimeric Antigen Receptors (CAR)-T Cells that Target the Non-shed Portion of Mesothelin as Therapeutic and Diagnostic Agents

National Cancer Institute Background Mesothelin (MSLN) is an excellent target for antibody-based therapies of cancer because of its high expression in many malignancies but lack of expression on essential normal tissues. Unfortunately, a large fragment of MSLN is shed from cancer cells, causing the currently available anti-MSLN antibodies (and immunoconjugates thereof) which bind to the […]

FlipDroppy Laboratory Dispenser for Solid Particles, Powders, and Beads

Max Planck Society Background In the laboratory, it is often necessary to measure and distribute dry particles, powders, and beads. This is usually done with scoops or measuring cups, which are challenging to use cleanly. Alternatively, this is done with mechanical devices involving moving parts, which are difficult to hermetically seal, difficult to clean, and […]

Optical Fiber Sensor for High Sensitivity Molecule Sensing

University of Victoria Background Molecule sensing is important in many fields. In the field of medicine, biomarkers are used to detect early signs of the disease and to develop personalized treatment to prevent the spread of disease and improve health outcomes. In the field of environmental monitoring, traces of heavy metals and organic contaminants are […]

Use of COX-2 Knock Out Monocytes and Osteoclasts to Activate and Expand NK Cells

University of California, Los Angeles Background Natural killer (NK) cells are a type of cytotoxic lymphocyte critical to the innate immune system. NK cells provide rapid responses to viral infection and are also crucial to inhibiting tumor formation. They are uniquely able to directly recognize and kill infected and cancerous cells. As such, there has […]

Des-acyl Ghrelin and Analogs as Novel Cancer Therapies

Cornell University Background Breast cancer is the most common cancer diagnosed in women and is second only to lung cancer in terms of mortality. Although most breast tumors occur after menopause when ovarian estrogen synthesis has ceased, most of these tumors remain estrogen dependent. The aromatase enzyme catalyzes the conversion of androgens to estrogens and […]

Method for Generation of Superparamagnetic Nanometric Iron Oxide Particles from Combustion of Iron Powders

Northeastern University Background Tiny iron oxide nanoparticles find many applications related to in vivo bioengineering and biomedicine mainly because of their super paramagnetic properties. Such applications are in the fields of medical diagnosis like bio-molecular magnetic resonance imaging (MRI), magnetic particle imaging (MPI), magnetic fluid hyperthermia (MFH), and therapeutics with targeted drug and gene delivery, […]

Compounds to Treat Melanoma, Renal Carcinoma, and Prostate Cancer

University of Arizona Background The treatment of all kinds of cancers leaves much to be desired in terms of an efficient treatment that is highly effective and has comparably lower side-effects. Treatments that target multiple kinds of cancers and are precise in their targeting are in high demand. The compound in this invention has the […]

Electrostatic Application of Antimicrobials

These liquid and powder sprays use antimicrobials extracted from plants and other natural sources to inhibit the growth of foodborne pathogens in meat products. This natural method is both effective and efficient while addressing the current issues associated with chemical-based food sanitizers including consumer health and cost.   Background: The innovators have used various natural […]

Additive Manufacturing of Complex Geometries of UHTC-Based Ceramics

Background Industry interest in ultra-high temperature ceramics (UHTCs) is skyrocketing. This family of materials boasts extremely high melting points, excellent shock resistance, mechanical strength, and chemical and thermal stability. Their many attributes render them ideal for aerospace applications, including wing leading edges for hypersonic vehicles and rocket nozzles. That said, the traditional method for manufacturing […]