Optimized Monospecific or Bicistronic Chimeric Antigen Receptor (CAR) Constructs Targeting CD19 and CD20

National Cancer Institute Background Patients with chemotherapy-refractory, diffuse large B-cell lymphoma (DLBCL) have poor prognoses. CD19 and CD20 are promising targets for the treatment of B-Cell malignancies. However, despite the initial promising results from anti-CD19 CAR therapy, only 30-35% of patients with DLBCL achieve remissions lasting longer than 2-3 years after anti-CD19 CAR T-cell therapy. […]

Genetically Modified Natural Killer Cells for Immunotherapy

Sabancı University Background Immunotherapy has made significant progress over the last decade and today there are multiple immuno-oncology therapies available to patients. Although there are other avenues of cancer treatment such as chemotherapy or radiation therapy, the adverse events, recurrence of malignancies and lack of specificity associated with these traditional therapies are driving researchers and […]

Novel Protease Inhibitors Provide Disease Resistance in Potatoes

Colorado State University Background Potato is a major staple crop, and necrotrophic bacterial pathogens such as Pectobacterium sp. and Dickeya sp. are major threats to potato production and therefore, global food security. These diseases cause over $40 million in annual loss to the US potato industry alone. Most lines of cultivated potato (Solanum tuberosum) are susceptible to soft rot […]

A Novel and Highly Efficient Method to Transfer DNA and Genetically Engineer Deinococcus Radiodurans with Multiple Biotechnology Applications

Western University Background The ability to genetically engineer Deinococcus radiodurans (D. radiodurans) is highly desirable due to the bacterium’s high survivability, which includes its capacity to resist damage from industrial processes that other bacteria cannot tolerate (e.g., treatment of mixed radioactive waste). Nevertheless, despite D. radiodurans unique characteristics, large-scale genetic modification of its DNA has […]

Wearable Light Sensors Based on Unique Features of a Natural Biochrome

­ ­ Background Exposure to sunlight’s harsh radiation has proven to be detrimental to our health. Ultraviolet (UV)-rays, infrared (IR) and to a lesser degree, visible light, all contribute to skin damage. Thus, measuring differing levels of sun exposure for individuals has become a popular preventative-care tactic. Current devices for generating such measurements, however, are […]

System and Method for Guiding People, Vehicles and Robots

University College Cork Background In busy industrial working environments, there can be multiple participants including humans, industrial mobile robots or vehicles all traversing the same space. The system provides customized and efficient routing guidance to allow for optimal use of the shared environment, whilst avoiding hazardous situations or interactions. Technology Overview Individual participants present in […]

Repurposed Medications to Treat Primary Biliary Cholangitis

Innovate Calgary Background Primary Biliary Cholangitis (PBC) is a progressive autoimmune liver disorder that ultimately leads to liver failure and death. It has been granted orphan status and affects approximately 1 in 3000-4000 individuals with over 90% of affected patients being female. Existing therapies are limited to ursodeoxycholic acid and the recently approved Ocaliva. However, […]

Impedance Calibration Device for Semiconductor Device

Northeastern University Background In semiconductor memory devices, data signals transmitted along a transmission line are reflected at the end of the transmission line. These reflected data signals may degrade the quality of the transmitted data signals. In order to reduce the reflection of the data signals, a termination resistor is usually coupled to the end […]

Novel Antibiotic Inhibitors

Penn State University Background There is a critical need for new drugs to treat infections of gram-negative antibiotic-resistant bacteria. The problem is especially urgent in hospital settings where resistance to multiple antibiotics is found in approximately 20% of infections caused by gram-negative Enterobacteriaceae. Gram-negative bacilli are the most common cause of hospital-acquired infection and the […]

Intelligence and Learning in O-RAN for 5G and 6G Cellular Networks

Northeastern University Background The traditional approach for cellular networks involved a rigid separation among the different entities that contributed to the network deployment, i.e., telecom vendors, operators, and chipset manufacturers. The performance optimization was mostly implemented by vendors during the equipment design process. As a result, the final appliances sold to operators (e.g., core network […]