First-in-class Therapy for Heart Failure with Preserved Ejection Fraction

Baker Heart and Diabetes Institute Background Heart failure with preserved ejection fraction (HFpEF), also known as diastolic heart failure, is estimated to affect 1.1 to 5.5% of the general population1 (at least 85 million people worldwide). Patients with HFpEF are commonly very symptomatic, with an elevated risk of rehospitalization and reduced quality of life due to […]

A Wine Production Yeast for use in Nitrogen-deficient Musts

Hub APTA Background The initial amount of nitrogen in grape must is vital for the fermentation process, being the second most nutrient consumed by yeast. However, nitrogen sources may be in limited concentrations in lower quality grapes. Slow or stopped fermentations due to low nitrogen content in the must and the inability of organic yeast […]

SHApe RElaxation (SHARE): A Method to Characterize the Poroelastic Properties of Swellable Soft Materials

Princeton University Background Hydrogels are commonly used in research and energy, manufacturing, agriculture, and biomedical applications. These uses typically require hydrogel mechanics and internal water transport, described by the poroelastic diffusion coefficient, to be characterized. Sophisticated indentation-based approaches are typically used for this purpose, but they require expensive instrumentation and are often limited to planar […]

Cationic Cobalt Complexes for the Catalytic Asymmetric Hydrogenation of Pharmaceutically Relevant Material

Princeton University Background The asymmetric hydrogenation of olefins is one of the most powerful reactions for the synthesis of single enantiomer products. Traditionally, Schrock-Osborn type catalysts have been employed for asymmetric hydrogenation. While effective, these catalysts carry a high cost, given the rhodium metal center. In view of these economic disadvantages, catalysts employing more abundant […]

Method to 3D-Print Engineered Living Materials

Princeton University Background Previous technologies for 3D-printing Engineered Living Materials composed of bacteria house in a polymeric matrix mixed the bacteria and pre-polymers together and 3D printed onto flat surfaces. However, the bacteria and pre-polymers are often very soft, so they will slump when printed on a surface, which hinders the ability to print complex […]

Dynamic Flash Vapor Chamber Cooling

University of California, Los Angeles Background Proper thermal management is critical for electronic devices that require high power consumption. They often generate large quantities of heat that result in temperature drifts and inconsistent device performance. When temperature changes occur in a transient manner, such as in pulsed devices, it can be particularly difficult to manage, […]

Bringing Light to NMR Spectroscopy

University of Manchester Innovation Factory Background This technology provides a universal solution to delivering multi-wavelength and high-intensity light to samples positioned inside a NMR spectrometer magnet. With this exciting new technology new smart materials, molecular photo-switches, photo enzymes, light-controlled gene expression and drug release, photo-chemical reactions, can be watched, studied and characterised in action by […]

Combifluor: In-line Monitoring of Pharmaceutical Manufacturing Processes Made Simple

University of Manchester Innovation Factory Background Impurities in drugs can be harmful to health, hence it is crucial to have excellent detection technology for application in pharmaceutical manufacturing. However, current technologies do not meet the high standards required to ensure their products do no harm to the human body. Several techniques have been applied in […]

Age-Related Macular Degeneration (AMD) Therapies

Australian National University Background AMD is the leading cause of blindness in the developed world predicted to affect 288 million people worldwide by 2040. The more common form, atrophic AMD, accounts for 90% of all AMD patients and has no known cure or therapy representing a major gap in the market. Technology Overview Researchers from […]