Fast and Accurate Tumor Antigen Discovery

University of Helsinki Background Clinical translation of cancer immunotherapies remains elusive since many patients fail to respond to current approaches. To overcome this challenge, immunotherapies must be engineered to target the specific vulnerabilities of each patient’s tumor. This greater degree of personalization can be achieved using neoantigens that direct the patient’s immune system to recognize […]

Sealable Microvalve that can be Repeatedly Opened and Sealed

Northeastern University Background The typical structure for a MEMS microvalve includes an orifice and a moveable plate that can be actuated to press against the orifice. When the plate does not press against the orifice, fluid can flow through the orifice and therefore through the valve. When the plate is pressed against the orifice, fluid […]

IFN-γ-Tethered Hydrogels Enhance Mesenchymal Stem Cell-Based Immunomodulation and Promote Tissue Repair

University of Michigan Background Human mesenchymal stem cells (hMSCs) are multipotent stem cells capable of differentiating into a variety of tissue types. Additionally, these cells exhibit immunomodulatory activity, making them an attractive avenue for treating chronic inflammatory and autoimmune disease. Studies show that treatment with hMSCs can help alleviate Crohn’s disease symptoms, but only for […]

Graphene Supported CryoEM Grid Development

University of Michigan Background Cryogenic electron microscopy (cryo-EM) is an electron microscopy technique whereby samples are cooled to cryogenic temperatures and embedded to a grid-mesh from structural analysis. Advances in this field have allowed scientists to visualize biologic samples at near-atomic resolution, making this technique a possible alternative to X-ray crystallography and NMR spectroscopy which […]

Hydroxychloroquine manufacturing: high-yield continuous flow synthesis

Virginia Commonwealth University Technology Overview Production of hydroxychloroquine, a possible treatment or prophylactic for SARS-CoV-2, by a high-yield continuous flow manufacturing process. The reagents are inexpensive and easy to source. Cost effective, semi-continuous flow methods and systems for synthesizing the antimalarial drug hydroxychloroquine (HCQ) in high yield are provided. The synthesis method that uses simple, […]

The COVID-19 High Performance Computing Consortium

Lawrence Livermore National Laboratory Background Fighting COVID-19 will require extensive research in areas like bioinformatics, epidemiology, and molecular modeling to understand the threat we’re facing and form strategies to address it. This work demands a massive amount of computational capacity. The COVID-19 High Performance Computing Consortium helps aggregate computing capabilities from the world’s most powerful […]

Mobile Accessible Pedestrian Signal (MAPS) System

IP Status: Issued US Patent; Application #: 15/897,854 Applications _x000D_ _x000D_ _x000D_ Navigation assistance for people with vision impairment _x000D_ Urban navigation system_x000D_ _x000D_ Traffic signals _x000D_ Subway and transit stations _x000D_ Malls, skyways, parks, theaters _x000D_ _x000D_ _x000D_ _x000D_ Key Benefits & Differentiators _x000D_ _x000D_ _x000D_ Real-time signal timing informs when to cross the […]

Improved Chest X-ray or Chest CT Scans for COVID-19 Screening

University of Graz Background Chest CT diagnosis can precede positivity on reverse transcriptase polymerase chain reaction testing for COVID-19 (RT-PCR). Early reports revealed low sensitivity of RT-PCR, ranging from 42% to 71%, and an initially negative RT-PCR may convert in a patient with COVID-19 4 days later. In contrast, the positive and negative predictive value […]

Non-contact Remote Force Measurement System for Minimally Invasive Surgeries and Cell Manipulation Applications

University of Waterloo Background A number of minimally invasive surgical procedures rely on different types of catheters to deliver treatment to hard-to-reach human internal organs. Magnetic-based propulsion technologies have recently been used with such catheters to assist with high precision manipulation tasks in these surgeries. However; the precision and effectiveness of these surgeries relies to […]