Highly Potent and Selective Inhibitors of CK1 as Treatment for Leukemia

Masaryk University Background B-cell chronic lymphocytic leukemia (CLL) is a lymphoproliferative malignancy with highly heterogeneous disease course and unclear pathogenesis. CLL is the most common adult leukemia in western countries, however it is still considered as incurable, despite extensive effort invested in development of novel therapeutic strategies. CLL is characterized by a monoclonal expansion of […]

High Accuracy Self-Navigation of Drones in Indoor Environments

Idaho National Laboratory Background Significant research has taken place in the drone industry for self-navigation technologies. However, this research has historically been focused on outdoor usage. These conventional drones rely on a strong GPS signal and a compass for successful navigation outside. These features give an outdoor drone vital position and heading information. However, both […]

Development of NLRP3 Inflammasome Inhibitors for Neuroinflammatory Conditions

Mount Sinai Health System Background Neurodegenerative diseases and inflammatory processes are closely involved. The innate immune system utilizes pattern recognition receptors to sense endogenous or exogenous pathogens. Among them, the inflammasome is a high molecular weight protein complex that elicits the activation of inflammatory caspases and processing of pro-interleukin-1b. In neurologic disorders, the NLRP3 inflammasome […]

FOXO1 Inhibition with AS1842856 as a Chemotherapeutic for Glioblastoma Multiforme and Basal-like Breast Cancer

The University of Texas Rio Grande Valley Background Due to poor survival rate associated with aggressive cancers like basal-like breast cancer (BBC) and glioblastoma multiforme (GBM), no current technology exists that can efficaciously treat BBC and GBM cancers. Technology Overview This technology is a targeted therapy for aggressive cancers: basal-like cancer (BBC) and glioblastoma multiforme […]

4-(5-Fluoropyridin-2-yl)-2azetidinones to Fight Against Drug-Resistant Pancreatic Cancer

The University of Texas Rio Grande Valley Background Around 95% of pancreatic tumors are driven by mutations in KRAS gene, subbed “undruggable” and prevalent in 5 drug-resistant pancreatic cancers. Currently, there is no effective medicine in the market for drug-resistant cancers. Technology Overview The present technology consists of compounds that demonstrate outstanding results against drug-resistant […]

Therapeutic 3D Nanofiber Membrane Prepared by Forcespinning

The University of Texas Rio Grande Valley Background Most wounds are treated with ointments and gels, and then covered with gauzes. This method is not very efficient, when it comes to skin wounds such as those caused by psoriasis (chronic autoimmune condition appearing on the skin in patches of thick, red, scaly skin with bleeding). […]

Microchannel Scaffolds and Microtube Electrodes for a Neural Interface System

The University of Texas Rio Grande Valley Background Although cultured neuronal networks have shown a variety of mechanisms of neuronal functionality, individual neuron interfaces have not yet been introduced during in vivo animal studies. State-of-the art electrophysiological techniques can only access a group of neurons, and this makes modality specific applications difficult. Technology Overview This […]

Device for Detecting Damaged Tissue in Chicken Meat

Universitat Politècnica de València Background The intensification of the production process of chicken meat has resulted in an increase of internal malformations, such as myopathies that cause broken muscle tissues, inner hemorrhages, necrosis and even heart attacks. A broken muscle tissue near the heart affects 5% of the total production and it causes big losses […]

Novel Herbicide Technology

Durham University Background Glyphosate based herbicides are the most widely used herbicides in agriculture and also play an important role in public amenity, sports & leisure and home & garden use. Glyphosate acts on the shikimate pathway, inhibiting the enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS), which catalyses the reaction of shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form […]