COBRA1/NELF-B as a Booster for Efficacy of CD8+ T Cell-Based Therapy

George Washington University Background CART cell therapy recently achieved success in treating blood cancers. Drugs Kymriah and Yescarta are FDA approved for treating hematological malignancies. However, existing T cell therapies are not effective in treating solid tumors, partly due to T cell exhaustion and lack of sufficient memory T cell populations.  Technology Overview GW researchers […]

PennHFD: A Specialty Corn Feed for Control of Enteritis in Poultry

Penn State University Background Avian necrotic enteritis (NE) is among the major diseases that affect the gastrointestinal health of broiler chickens. Clinical and subclinical forms of NE negatively impact weight gain, feed conversion ratio, and may result in death. NE is caused by pathogenic strains of Clostridium perfringens (CP), a Gram-positive bacterium. Previously, NE was effectively controlled […]

Monoclonal Antibodies to S and N SARS-CoV-2 Proteins

Penn State University Technology Overview Penn State Inventors have generated novel panels of monoclonal antibodies (mAbs) to the spike (S) and nucleocapsid (N) structural proteins of SARS-CoV-2. Reported results demonstrate that the panels may be used to characterize and define: structural and antigenic features of SARS-CoV-2, vaccine impacts on current infections, mutations that lead to […]

Co-opting Regulation Bypass Repair of Genetic Diseases

Penn State University Technology Overview Penn State Inventors have developed a novel CRISPR-mediated gene correction strategy, named Co-opting Regulation Bypass Repair or “CRBR”, that maintains endogenous regulatory regions but bypasses a spectrum of genetic defects. As seen in , CRBR utilizes homologous independent targeted insertion, part of the NHEJ repair pathway, to insert a cassette that […]

Drift-Free and Calibration-Free Measurement of Analytes

University of California, Santa Barbara Background Existing electrochemical biosensor architectures all require calibration in order to correct for inter-sensor variation arising due to variation in fabrication and intra-sensor variation caused by drift in order to achieve accurate results. It would be advantageous to develop electrochemical biosensor platforms that work stably and autonomously over long periods […]

Virtual Reality Medical Training System

Thomas Jefferson University Background Hospitals frequently use code names to alert their trained personnel to an emergency event. Advanced Cardiac Life Support (ACLS) Code Blue is one of the most universally recognized codes; it alerts staff of a medical emergency where a patient is in immediate danger due to cardiac arrest. Despite extensive medical training […]

Gene Profiling for Accurate Diagnosis of Thyroid Cancer Nodules

Cornell University Background Thyroid cancer typically presents as a thyroid nodule, with 5 – 15% of all thyroid nodules proving to be malignant. Microscopic examination of a thyroid biopsy sample, typically obtained by the fine needle aspiration (FNA) procedure, has been the gold standard in preoperative diagnosis of thyroid nodules. However, this procedure remains subjective, […]

Fast and Reliable Neutralization Antibodies Assay for AAV Gene Therapy

University of Minnesota Background Adeno-associated virus (AAV) vectors are a common platform for in vivo gene therapy applications and have been used successfully in clinical trials in patients with blood diseases and blindness. The presence of pre-existing neutralizing antibodies in about 50% of patients significantly decreased the clinical utility of AAV vectors. The prevailing assays […]

Generating ECG/EKG Signals from PPG Sensor Data

Queen’s University Background Electrocardiogram (ECG/EKG) is the electrical measurement of cardiac activity. It is a common and non-invasive method used to accurately detect heart problems and monitor cardiac health. ECG/EKG devices are typically used in hospitals and doctor’s offices. There are also a number of portable ECG/EKG devices for short-term ambulatory monitoring. However, there are […]