Continuous, Environmentally Friendly Synthesis of fine Chemicals Exemplified for Indocyanine Green

University of Sussex Technology Overview The current synthesis of pharmaceuticals such as indocyanine green (ICG) using batch production methods is time-consuming wasteful in terms of energy and solvent use. Researchers at the University of Sussex have developed a new methodology which revolutionises the production of this valuable medicine that has a multi-million dollar global market. […]

Environmentally Friendly Anti-Icing and De-Icing Coating

Background Ice formation and accretion on aircrafts, ships, power lines, oil rigs and automotives is a severe hazard, which not only endangers human life, but also causes enormous financial losses. For example, when ice accumulates on the exposed surfaces of airplanes, it leads to undesirable increase in drag, decrease in lift and reduction in visibility. […]

Modular Approximation for Whole-Lung Volume Spatial Deposition Measurements

University of Delaware Technology Overview University of Delaware researchers have developed a new whole-lung modeling approach to improve preclinical trials of inhaled medicine. Measuring where aerosols deposit is an important factor in predicting a medicine’s impact on lungs, but current models are not adequately able to provide this information under breathing conditions. This innovation allows […]

Cell Culture System for Investigating Drug Delivery

University of Vienna Background Up to now, particle-cell interaction experiments on a cell monolayer are predominantly performed in a multiwell plate (e.g. 96-well plate). In this conventional horizontal experimental setup, sedimentation or flocculation characteristics of the particles investigated can greatly influence the outcome of the particle-cell interaction experiment. A fast sedimentation velocity of particles enhances […]

Novel Immunotherapy to Treat Ovarian and other Cancers

University of Kentucky Background Ovarian cancer is the most deadly gynecologic malignancy. The American Cancer Society estimates 19,880 new diagnoses and 12,810 deaths in 2022. Approximately, 80% of individuals are diagnosed with advanced-stage disease with a 5-year survival of only 40%. Patients with advanced ovarian cancer are treated with cytotoxic chemotherapy (carboplatin and paclitaxel), which […]

Novel Toll-Like Receptor (TLR) 7/8 Agonist Antibody-Drug Conjugates

SUNY Research Foundation Background Toll-like receptor (TLR) agonists are immunostimulants that are often used as vaccine adjuvants. They activate the adaptive immune system leading to a more robust antiviral effect, and can also be used to unmask the immunosuppressive tumor environment and initiate a robust anti‐tumor response by the immune system. A number of TLR […]

Thymine DNA Glycosylase (TDG) as a Novel Target for the Treatment of Melanoma and Other Cancers

Fox Chase Cancer Center Background Two known epigenetic alterations in cancer are CpG island methylation (CIMP) and genome-wide hypomethylation. In particular, about 20-40% of melanomas, triple-negative breast cancers, serous ovarian, and serous endometrial cancers are characterized by a pervasive genome-wide hypomethylation that can be documented by mining the TCGA methylation data. Demethylating agents (e.g., decitabine […]

Bioactive Peptides: Inhibition of Neuroinflammation & Neurodegeneration

University of Oklahoma Background There is currently no treatment available to stop or slow the progression of Alzheimer’s disease (AD). A vicious cycle between neuroinflammation and neurodegeneration is triggered and sustained by amyloid β (Aβ) soluble aggregates in the brain of patients with AD. The defense proteins CAP37, cathepsin G (CG) and neutrophil elastase (NE), […]

Chemically Modified Curcumin for Promoting Resolution of Inflammation

Stony Brook University Background It has long been known (especially in Asian countries, e.g., India, China) that the natural spice curcumin, an active ingredient of turmeric, has broad health benefits. More recently, Stony Brook University inventors have synthesized and tested the safety and efficacy of a series of novel chemically-modified curcumins (CMCs) which have shown […]

Innovative Gas Turbine Architecture

University of Notre Dame Background Gas turbines are widely used for propulsion mobility applications, including flight, ground, and marine vehicles, as well as for land-based power generation. Conventional gas turbines engines ingest air from the atmosphere which is compressed, heated through fuel-added combustion, and expanded to produce power. Key considerations when selecting an engine include […]