Anti-CD99 Antibodies Cytotoxic to Leukemia

New York University Background CD99 is a type-1 transmembrane protein that is upregulated in many types of cancers including, hematopoietic and bone malignancies. Prior work (Chung et al. Sci Transl Med 2017) has established CD99 as a therapeutic target for Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS). In this study, a mouse monoclonal antibody […]

Oral Insulin Delivery Nanoparticles for Diabetes Treatment

New York University Background Diabetes is an increasingly prevalent chronic disease which affects approximately 10% of the world’s population and is the 7th leading cause of death worldwide. Insulin therapy is currently the standard of care in controlling and regulating blood glucose levels in diabetes; however, current methods of administration (by subcutaneous injection) are not […]

Photoactivatable Lipid Nanoparticles for Drug Delivery

New York University Background Lipid nanoparticle (LNP) systems are well-established drug delivery platforms for multiple therapeutic modalities, including small molecule drugs and exogenous nucleic acids. Encapsulation of drugs in LNPs affords several advantages: ability to systemically distribute cytotoxic and/or liable drugs, enhanced accumulation at tumor sites, and a reduction in toxic side effects. One fundamental […]

Automated Antidote Injector for Opioid Overdose Prevention

University of Victoria Background More than 110,000 people died from opioid overdose in 2017, according to the World Health Organization – and opioid use has only continued to grow since. The United States Center for Disease Control reports that more than 50,000 people died from opioid-related overdose in 2019 in that country. The COVID-19 pandemic […]

3D Printing Method for Continuous Fiber-reinforced Thermoset Composites

University of Colorado Boulder Background Continuous fiber-reinforced thermoset composites, with their superior combination of stiffness, strength, and lightweight, have been leading contenders in various applications ranging from aerospace to ground transportation. Conventional manufacturing methods, such as the injection molding, filament winding, and pultrusion, use expensive molding tools to shape the resin and fibers. Mass production […]

ARumenamide, Sodium Channel Potentiators, have the Potential to Cure Epilepsy and Related Neurological Disorders

Simon Fraser University Background The World Health Organization (WHO) reports that epilepsy, which affects about 50 million people globally and raises the risk of early death, is one of the most prevalent neurological conditions. However, when properly identified and treated, about 70% of epilepsy sufferers are seizure-free. Seizures produced by epilepsy emerge from numerous parts […]

Magnetically Enhanced Plasma Treatment of Cancer

GW researchers enhanced a method to selectively kill cancer cells with cold atmospheric plasma (CAP) by concurrently exposing the cancer cells to a static magnetic field. Previously, GW researchers invented a method to selectively kill cancer cells with cold atmospheric plasma (CAP), while leaving neighboring normal cells unaffected.  In the present invention, the researchers devised an enhanced […]

Process of Production of Roll and Submicrometric Membrane of Ga2O3 by Ion Implantation

Instituto Superior Técnico Background The process of producing rolls and submicron membranes from monocrystalline materials has been extensively studied and developed in recent years due to its technological potential in different electronic, optical, and mechanical applications. Most of the technologies developed need to use a sacrificial layer to obtain thin layers/membranes of a dielectric, semiconductor, […]

PROTAC – Based Combination Therapy for the Treatment of Cancer

Fox Chase Cancer Center Background PROTACs (Proteolysis-Targeting Chimeras) represent a promising new class of drugs thatselectively degrade proteins of interest from cells. PROTACs are small molecules with two functional ends, a small-molecule end that binds to the protein of interest and the other end that binds to an E3 ubiquitin ligase. The PROTAC component recruits […]

Inflatable Vaginal Stanched Pessary

National Sun Yat-sen University Background Uterine prolapse is caused by pregnancy, long-term weight-bearing, and muscle/collagen loss after menopause. A woman has an 11% chance of undergoing surgery for prolapse. For different races and backgrounds, women have unlike vaginal sizes. In the past, doctors usually spend a lot of time on choosing the size, and the […]