Antiviral Prodrugs of ANP (Cidofovir) with Increased Bioavailability and Potential Effectiveness Against Covid-19

USC researchers have developed a novel prodrug platform that addresses all three issues with ANP antivirals and are possibly effective against Covid-19. The technology provides a solution for the identification and synthesis of cidofovir prodrugs and related ANP antivirals that are much more potent then the parent drugs in vitro. The prodrugs show 10x higher oral bioavailability and data suggests better safety profiles. Several of these compounds have been shown to be orally and locally effective in preventing or treating DNA virus infections in animal models. Stefan Schweizer stefans@usc.edu (213) 821-6067

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