Biodegradable and Multifunctional Neural Block Devices

Penn State University Background
Effective methods of peri- and post-operative pain management are critical to ensuring patient recovery and satisfaction. In contrast to systemic and epidural anesthetic procedures, peripheral nerve block offers specific, localized effects, leading to benefits including reduced consumption of opioids, shortened hospitalization duration, lower drug concentration requirements, and increased physical therapy compliance. Despite these advantages, less than one in five eligible procedures utilizes this technique due to complications arising from extended dwell time and necessary removal of nondegradable catheters. Application of this biodegradable catheter would have clinical applications both in ambulatory surgery and also in procedures that require precise delivery of pharmaceutical agents.
Technology Overview
Leveraging a versatile and biocompatible citrate-based material platform, researchers have developed a high-strength, elastic and kink resistant, rapidly degradable biphasic catheter. The citrate-based elastomer material swells when surrounded by body fluid, anchoring the catheter to tissue while eliminating the removal requirement, thus solving the conflicting need to attain device security during treatment and detachment post-treatment. This fully biodegradable, tissue adherent peripheral nerve catheter is also capable of sustained drug delivery without damage to surrounding tissue ().
Stage of Development
Technology readiness level 1-3
Opportunity
Seeking research collaboration and licensing partners.