C2014-04 – Removal of Low Molecular Weight Heparin as a Treatment for Heparin Overdose

Technology # 14-04 A Technology as a Treatment for Heparin Overdose Heparin is an anti-coagulant that is commonly used in surgery to prevent blood from clotting during procedures such as kidney dialysis, heart bypass surgery, stent implementation, indwelling catheters and knee and hip replacements. In about 5% of the cases of heparin usage, the patients experience uncontrolled bleeding which can be dangerous, especially for children. Children are usually given a particular form of heparin, low molecular weight heparin. For this form of heparin, there is currently no way to remove heparin from the blood in case of uncontrolled bleeding or heparin overdose, and the only treatment is to use an antidote, protamine sulfate. However protamine sulfate is difficult to administer properly, and causes allergic reactions in patients that are allergic to fish. The invention is available for licensing. For interested parties seeking further information, feel free to contact: Mark Allen Lanoue Technology Manager / Tech Ventures University of Arkansas (479) 575-7243 malanoue@uark.edu Technology Ventures ventures@uark.edu 479-575-7243

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