Cannabinoids Detection kits – 2019-076

Across the country states are legalizing marijuana for medical and/or recreational uses. As the legal landscape is rapidly changing, there are growing concerns about marijuana impairment while driving or in the workplace, and an increasing demand by law enforcement personnel for the capability to differentiate industrial hemp crops from recreational marijuana. Quantification of cannabinoids in human biological samples and plant material is currently performed in centralized laboratory settings. However, there are no reliable tests that can be employed on-site for the determination of cannabinoid content in a variety of sample matrices. FIU inventorshave developed aptamers-based sensors and methods for the detection ofcannabinoids in body fluids. One aptamer specifically binds to tetrahydrocannabinol(THC) with nanomolar dissociation constant and does not bind to structurallysimilar cannabinoids such as cannabidiol and cannabinol. This aptamer alsobinds to the urinary metabolite of THC, THC-COOH. The second aptamer binds tothe synthetic cannabinoids UR-144 and XLR-11, each with nanomolar dissociationconstants, and does not bind to any naturally occurring cannabinoids. Anne Laure Schmitt Olivier aschmitt@fiu.edu 305-348-5948

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