Combifluor: In-line Monitoring of Pharmaceutical Manufacturing Processes Made Simple

University of Manchester Innovation Factory Background
Impurities in drugs can be harmful to health, hence it is crucial to have excellent detection technology for application in pharmaceutical manufacturing. However, current technologies do not meet the high standards required to ensure their products do no harm to the human body. Several techniques have been applied in monitoring those toxic substances, such as liquid chromatography (LC) and total organic carbon (TOC). However, LC is time-consuming thus, has a low sampling rate, and the precision of TOC is low due to difficulty in explaining the results obtained. Other conventional spectroscopic methods have similar drawbacks to TOC. A quick and precise technology to build in situ monitoring for manufacturing sites, ensuring the quality of drugs produced, would be highly advantageous.
Technology Overview
Combifluor is an instrument applying light-induced fluorescence (LIF) processing, which demonstrates quick and precise probing for the impurities of drugs. A designed LED array with filter can emit different combinations of specific light wavelengths, targeting impurities, to produce relevant fluorescence response probed by detector. An absorption probe is integrated into the design to calibrate the rightness of LIF detection. It is built upon LIF technology to combine the sensitivity enhancements of fluorescence, and the multivariate selectivity enhancement delivered by 4-way kinetic-excitatione mission data sets. Through optimisation of the design, Combifluor is a precise real time LIF-measurement tool for inline monitoring of pharmaceutical manufacturing processes.
The team is keen to talk to instrument manufacturers to discuss development of the technology into a commercial product, and the manufacturing of the device for pharmaceutical company end-users.

Related Blog

Smart, interactive desk

Get ready to take your space management game to the next level with the University of Glasgow’s innovative project! By combining the

Mechanical Hamstring™

University of Delaware Technology Overview This device was created to allow athletes who suffer a hamstring strain to return to the field

Join Our Newsletter

                                                   Receive Innovation Updates, New Listing Highlights And More