COVID-19 Related – Anabaseine Derivatives to Treat Mucus Clearance Defect in Airway Diseases

Mucus clearance is a critical defense mechanism of airways to maintain proper respiratory function. Excessive mucus secretion contributes to the pathology of many respiratory diseases such as COPD, asthma, and cystic fibrosis. Research performed at the University of Alabama at Birmingham by Dr. Raju & colleagues identified α7 nicotinic acetylcholine receptor (α7nAChR) a physiologic regulator of mucus clearance and identified a small molecule agonist that can restore mucociliary clearance by augmenting epithelial ion transport and mucosal surface hydration. The market for antiasthmatics and COPD drugs was $52 billion in 2019 and is expected to grow at a CAGR of 4.5% from 2019-2023. Meanwhile the global cystic fibrosis therapeutics market is expected to reach $13.9 billion by 2025, a CAGR of 16.7% from 2017. Karen Bernard kbernard@uab.edu (205) 934-8826

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