Detecting and Monitoring Inflammatory Bowel Disease in Dogs (Stool-Immune Test)

Colorado State University Background
Inflammatory Bowel Disease (IBD) is a common disease in dogs with a variety of proposed causes, and can cause vomiting, diarrhea, and weight loss. Diagnosis of IBD typically requires a combination of laboratory testing and an endoscopic biopsy procedure, which is expensive and requires general anesthesia. Indirect examination methods, including blood work and radiographs, lack sensitivity and specificity to reliably diagnose the disease. Therefore, novel diagnostic methods are needed to rapidly and correctly diagnose IBD.
Technology Overview
A group of investigators in the Center for Immune and Regenerative Medicine at CSU has discovered that dogs with IBD develop an immune response against their own gut bacteria, producing high levels of immunoglobulin G (IgG) bound to the surface of gut bacteria, which in turn triggers intestinal inflammation. Based on this new understanding of the pathogenesis of IBD in dogs, they have developed a new diagnostic test (Stool-Immune) for IBD that is rapid, sensitive, and non-invasive. The test uses flow cytometry to detect and quantitate the amount of IgG bound to gut bacteria, using small stool samples. The level of IgG binding can be used with high accuracy to distinguish dogs with IBD (high IgG binding) from dogs with healthy GI tracts (low IgG binding) ().
The Stool-Immune diagnostic test diagnoses inflammatory bowel disease (IBD) in dogs using stool specimens. The accuracy and sensitivity of Stool-Immune test is superior to any diagnostic currently on the market, and can be run using fresh or frozen stool specimens. Use of this test can avoid endoscopic biopsy for an IBD diagnosis, and could also be used to monitor the effectiveness of treatment, since the test provides a quantitative estimate of the intensity of the immune response against commensal bacteria in dogs with IBD.
Benefits

Use of small stool samples to rapidly diagnose IBD
Non-invasive testing, avoids need for endoscopic biopsies.
Greater sensitivity and specificity than any indirect tests on market currently.

Applications

Diagnostic for IBD in canines
Test has potential to expand to the diagnosis of IBD in other animal species, including humans 

Opportunity
Colorado State University is seeking a licensing partner to develop and market the Stool Immune test.

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