Disialyl Glycans (as Immunoregulators, Prebiotics, and Antimicrobials) as Potential Therapeutics

Up to 20% of preterm infant deaths are caused by necrotizing enterocolitis (NEC). The American Academy of Pediatrics have shown that breast milk lowers rates of NEC in preterm infants, and while Disialyllacto-N-tetraose, a glycan in breast milk, has been identified to prevent necrotizing enterocolitis in newly born children, the cost of producing this glycan is too high. Researchers at the University of California, Davis have engineered a novel homolog to Disialyllacto-N-tetraose which has been shown to prevent necrotizing enterocolitis and can be produced quickly and cost-effectively. Maris Apse mpapse@ucdavis.edu 530-754-8718

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