DNA Sensors Using Single-Walled Carbon Nanotubes – IP 0610

The properties of DNA that enable it to self-replicate and self-assemble have also been used in recent years to detect sequences of DNA that identify specific genes. Through a process of hybridization, a single strand of DNA can be used as a probe to find a complimentary section of DNA that identifies a gene. Polymorphisms, or mutations in the genetic sequence can be used to positively identify certain viral strains, disease states, or other genetically significant differences. This group of technologies is based on a novel process of functionalizing carbon nanotubes so that they may be used as electrodes to directly measure the difference in electrical conductivity between a single strand of DNA and a completed double helix formed through hybridization. The core discovery uses nanogaps in single- walled carbon nanotubes (SWNTs) to create an effective platform for DNA sensing and recognition. Anne Laure Schmitt Olivier aschmitt@fiu.edu 305-348-5948

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