Dynamic Fabric Phase Sorptive Extraction (DFPSE) – IP 1319

Dynamic Fabric Phase Sorptive Extraction (DFPSE)disks are capable of extracting target analyte(s)exhaustively from unmodified sample matrices containing high volume of matrixinterferents including particles, debris, biomass, cells, tissues, proteinswithout employing any sample clean-up exercise. The technologyprovides the process of making DFPSE disks by chemically immobilizing organicpolymers or ligands on a flexible substrate resulting in an exhaustive samplepreparation (cleaning/preconcentration) to accomplish high recovery of targetanalyte(s) in a short period of time. DFPSE providesflexible, open, flat and easily accessible surface for rapid sorbent-analyteinteraction. Since both the surfaces and inner matrix of the substrate arecoated with inherently porous sol-gel hybrid materials, the accessible surfacearea for DFPSE media are enormous leading to a very high sample capacity. In DFPSE, any organicsolvent or solvent mixture can be used as the eluent/back-extraction solventsince the composite coatings are chemically bonded to the substrate. As aresult, same sample can be analyzed in GC/HPLC/CE if a mutually compatiblesolvent is chosen for the back-extraction. Utilization of proper solvent forback-extraction also ensures no analyte carry-over that may hinders futureextractions or compromises the quality of analytical data. Also, highenrichment factors obtained in DFPSE eliminates the necessity of time consumingsolvent evaporation and sample reconstitution step. Due to the strongcovalent bonding between the hybrid coating and the substrate, the coatingdemonstrates high chemical stability and can be exposed to high acidic (pH 1)and basic (pH 12) environment without compromising the integrity of theextraction disk. DFPSE allows user touse disks coated with polymers of different polarity. As a result, if theobjective of the analytical scheme is to extract analytes with differentpolarity, multiple disks coated with different polarity can be employed. At theend, all extracted analytes can be back-extracted in the same back-extractionsolvent. Anne Laure Schmitt Olivier aschmitt@fiu.edu 305-348-5948

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