Family of PFKFB3 Inhibitors with Anti-Cancer Activities (07010)

Family of highly specific small molecules; May suppress metabolism of cancer cells and proliferation of multiple cancer types; High oral bioavailability. There are an estimated 15 million people living with cancer in the U.S. alone. With a 5year survival rate of only 67%, cancer is among the leading causes of death worldwide. Due to the disease’s high prevalence and mortality, there is an urgent need for effective methods to treat it. To address that need, researchers at the University of Louisville have developed 6phosphofructo-2-kinase/fructose-2,6bisphosphatase 3 (PFKFB3) inhibitors that may be used as anti-cancer therapeutics. By inhibiting PFKFB3, the compounds suppress cancer cells’ metabolism, thereby impairing the growth of tumors. The compounds have high oral bioavailability and have been shown to successfully suppress growth of tumors in mice and in human cancer cells in vitro. Rob Smith 502-852-3027

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