Fragment-Based Stabilization Of 14-3-3/Client Protein-Protein Interactions

UCSF and Technical University of Eindhoven investigators have identified molecular fragments that stabilize 14-3-3/phospho-peptide and 14-3-3/phospho-protein interactions. Further structure-guided and empirical medicinal chemistry will lead to a drug lead for the most advanced target (estrogen receptor). Catherine Smith Catherine.Smith2@ucsf.edu 510-646-0631

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