High Throughput Measurement of DNA Base Lesion Repair Capacity – IP 1558

FIU inventors developed a novel fluorescence-based technology for measuring base excision repair capacity in whole cell lysates. Currently, base excision repair is measured through monitoring decreases of DNA damage, which lacks accuracy. Additionally, current plasmid transfection-based assays are hinged by the limited amount of plasmids containing various types of DNA lesions and the inefficiency of introduction of plasmids into different mammalian cells limiting the use of this method at a high throughput scale. The cell transfection-based technology for measuring base excision repair also prevents its application in measuring DNA repair capacity in human tissue. The proposed technology is simple, fast, and can be used for high-throughput measurement of base excision repair capacity of cell lysates for cells obtained from human population studies and patient tissue, and allows for screenings of anti-cancer drugs and environmental toxicants that can inhibit base excision repair pathways for disease prevention. in multiple OSs, while also opening up avenues for future developments and enhancements. Anne Laure Schmitt Olivier aschmitt@fiu.edu 305-348-5948

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