Hydrogen Peroxide-Activated Compounds as Selective Anti-Cancer Therapeutics

Activation via hydrogen peroxide Low off-target effects in non-cancerous cells The design of DNA-based agents for cancer treatment has slowed dramatically because of the perception that these agents will have high levels of off-target effects on healthy, non-cancerous cells. Normal off-target effects include modification or interaction of DNA in these non-cancerous, highly replicating cells. This off-target reactivity limits tolerated doses of these agents and decreases the efficacy of these drugs. UC researchers have developed novel anti-cancer compounds that are activated by and specifically target cancer cells associated with elevated levels of hydrogen peroxide and other reactive oxygen species. In the absence of these species, the compounds will be less capable of exerting a cytotoxic mechanism on normal cells. For discussions around learning more or licensing this technology, please contact Jill Uhl today. Jill Uhl uhlje@ucmail.uc.edu (513) 558-5621

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