Hydroxychloroquine manufacturing: high-yield continuous flow synthesis

Virginia Commonwealth University Technology Overview
Production of hydroxychloroquine, a possible treatment or prophylactic for SARS-CoV-2, by a high-yield continuous flow manufacturing process. The reagents are inexpensive and easy to source.
Cost effective, semi-continuous flow methods and systems for synthesizing the antimalarial drug hydroxychloroquine (HCQ) in high yield are provided. The synthesis method that uses simple, inexpensive reagents to obtain the crucial intermediate 5-(ethyl(2-hydroxyethyl)- amino)pentan-2-one, vertical-integration of the starting material 5-iodopentan-2-one and the integration of continuous stirred tank reactors. 
Further Details
Yu, E., Mangunuru, H., Telang, N. S., Kong, C. J., Verghese, J., Gilliland Iii, S. E., Ahmad, S., Dominey, R. N., & Gupton, B. F. (2018). High-yielding continuous-flow synthesis of antimalarial drug hydroxychloroquine. Beilstein journal of organic chemistry, _14_, 583–592. https://doi.org/10.3762/bjoc.14.45
Stage of Development
The technology presented is a manufacturing process that could be used to produce it at scale. There are ongoing clinical trials applying HCQ to COVID-19.
Prophylaxis clinical trial: https://clinicaltrials.gov/ct2/show/NCT04308668?term=Hydroxychloroquine&cond=%22Acute+Lung+Injury%22&draw=2&rank=2
Treatment clinical trial: https://clinicaltrials.gov/ct2/show/NCT04321616?term=Hydroxychloroquine&cond=%22Acute+Lung+Injury%22&draw=2&rank=1
Pharmaceutical manufacturing: the process has been validated on bench scale continuous-flow reactors

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