Metabolic Engineering Of The Shikimate Pathway Via Synthetic Operons

Investigators at UC Berkeley have developed an alternative approach to engineer the shikimate pathway in E. coli. The native pathway was reconstructed in a modular fashion to remove bottlenecks and optimize the flux and production by improving promoters and regulatory elements. Using these modifications to the shikimate pathway resulted in strains that produce high yields of tyrosine and other valuable intermediates such as shikimate and dehydroshikimate and also dehydroquinate and quinate. This pathway engineering can also be used for production of other aromatic amino acids, tryptophan and phenylalanine at high yields as well as additional intermediates such as phenylpyruvate, anthranilate, and others. These constructed metabolic pathways can be transferred to other strains or microorganisms. Laleh Shayesteh lalehs@berkeley.edu 510-642-4537

Related Blog

Smart, interactive desk

Get ready to take your space management game to the next level with the University of Glasgow’s innovative project! By combining the

Mechanical Hamstring™

University of Delaware Technology Overview This device was created to allow athletes who suffer a hamstring strain to return to the field

Join Our Newsletter

                                                   Receive Innovation Updates, New Listing Highlights And More