Metabolic Engineering Of The Shikimate Pathway Via Synthetic Operons

Investigators at UC Berkeley have developed an alternative approach to engineer the shikimate pathway in E. coli. The native pathway was reconstructed in a modular fashion to remove bottlenecks and optimize the flux and production by improving promoters and regulatory elements. Using these modifications to the shikimate pathway resulted in strains that produce high yields of tyrosine and other valuable intermediates such as shikimate and dehydroshikimate and also dehydroquinate and quinate. This pathway engineering can also be used for production of other aromatic amino acids, tryptophan and phenylalanine at high yields as well as additional intermediates such as phenylpyruvate, anthranilate, and others. These constructed metabolic pathways can be transferred to other strains or microorganisms. Laleh Shayesteh 510-642-4537

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