Method For Controlling Cell Adhesion And Growth On Biopolymer Surfaces

Endothelial cell seeding is an effective method of preventing thromboembolism on surfaces of cardiovascular implants and devices. To leverage this effect, researchers at UC Berkeley have investigated the adhesion and cytoskeleton morphology of endothelial cells seeded on low-density polyethylene surfaces. These studies have resulted in the development of a method for controlling cell adhesion and growth on biopolymer surfaces by performing changes in the surface biochemical properties. The novelty of this method relies on the selective use of specific treatment conditions to produce certain surface functionalities that control cell affinity for the polymer surface, followed by adsorption of different proteins for growth factor control Marc Oettinger marc.oettinger@berkeley.edu 510-642-8355