Method of Treating Genitourinary Disorder Using Mesenchymal Stem Cells and Cultured Media

The invention details a novel, noninvasive method to treat stress urinary incontinence (SUI) and other pelvic floor disorders using bone marrow-derived mesenchymal stem cells (BM-MSCs) and their secreted cytokine proteins that have been cultured into a media endowed with therapeutic properties. Repair and regeneration effects are promoted upon intravenous administration for structural and functional recovery of tissues involved with genitourinary disorder, like the external urethral sphincter and smooth muscle tissue. Leak point pressure (LPP), a measurement indicator for continence, was shown to recover upon treatment using BM-MSCs and cultured media. Method, characterization, and results using BM-MSCs and cultured media have been established in a preclinical rat model Michael Hansen hansenm@ccf.org 216-444-0386

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