Monoclonal Antibodies to S and N SARS-CoV-2 Proteins

Penn State University Technology Overview
Penn State Inventors have generated novel panels of monoclonal antibodies (mAbs) to the spike (S) and nucleocapsid (N) structural proteins of SARS-CoV-2. Reported results demonstrate that the panels may be used to characterize and define: structural and antigenic features of SARS-CoV-2, vaccine impacts on current infections, mutations that lead to vaccine escape, and the viral replication cycle.
Both mouse and rabbit mAbs to the S protein were developed. Neutralizing activity was observed from anti-S protein mouse and rabbit mAbs. Anti-S protein mAbs are expected to have the greatest utility in the identification, development, and validation of therapeutics. Mouse and rabbit SARS-CoV-2-specific N-reactive mAbs were also developed. Anti-N protein mAbs may have pronounced utility in developing and/or validating immunoassays and increased sensitivity as compared to Anti-S mAbs. The specificity of the Anti-N protein mAbs is especially useful considering the high level of amino acid conservation between N proteins of SARS-CoV-2 as compared to other coronaviruses. Anti-N mAbs may also have utility in detecting early-stage infection.
All mAbs were assessed for their functional activities, including virus neutralization, antigenicity, and epitope specificity.
Further Details
High-quality antibodies are key reagents that facilitate both discovery research as well as the identification, development, and validation of novel therapeutics and diagnostics. Since both the S and N proteins are the major targets of the antibody response following infection with SARS-CoV-2, these novel mAb panels will enable continued research on the role of these proteins during the replication cycle of the virus and how these key proteins are recognized by the immune system.
Antibodies are available for transfer to industry and academic partners.

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