Natural Treatment for Ventilation Induced Lung Injury (UA16-075)

This invention is the use of bixin, a NRF2 inducer, to reduce the lung damage caused by mechanical ventilation. Bixin was found to suppress inflammatory mediators, reduce alveolar capillary leakage, and protect against DNA oxidative damage. This can be used to treat ventilator-related lung damage in patients with COVID-19.Background:Mechanical ventilation is used to assist patients who have difficulty breathing spontaneously in conditions such as lung trauma, chronic obstructive pulmonary disease, acute respiratory distress syndrome, apnea, severe asthma, and patients under general anesthesia. Ventilator-induced lung injury may result from mechanical ventilation, which is the cyclic stretching and overdistension of the lung tissues. This causes inflammation and leads to acute lung injury. There are no effective pharmacological strategies to reduce the negative effects of mechanical ventilation.Learn more at https://bit.ly/UA16-075 Anne Spieth annes@tla.arizona.edu 520-626-1577

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