Near-Infrared Ray Exposure System for Biological Studies – IP 1556

Near infrared ray (NIR) basedtechnology is emerging as an important tool for studying different aspects ofbiological systems as it offers several advantages over the ultraviolet andvisible spectral range, such as minimum absorption and scattering, and deeperin vivo penetration. Further, when applied in conjunction with nanoparticles,NIR irradiation can be employed for treating in vivo models of cancer or otherdiseases. Unfortunately, due to the difficulty in minimizing or avoidingdamaging thermal effects on the brain cells, this combined technique haslargely been restricted to models of peripheral cancer therapy. In addition,several instruments are required for simultaneously applying a photonicirradiation source and optically evaluating its thermal effects on brain cellsand/or other tissues. FIU inventors have developed aNIR exposure system for conducting photonic and optical treatments onbiological samples with additional functions including temperature monitoringand real-time microscopic imaging. The system can also be combined withnanoparticles (NPs) treatment to accomplish non-invasive, on-demand drugtargeting, brain cell specific gene delivery, and magnetizedphoto-biomodulation for treating various CNS or peripheral disorder models. Anne Laure Schmitt Olivier aschmitt@fiu.edu 305-348-5948

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