New Targets for Therapy (Casanova)

A parallel approach to Charlie Rice’s is being taken by Jean-Laurent Casanova, a superb human geneticist who has identified many genes whose mutation causes unusual susceptibility to infectious agents such as the bacterium that causes tuberculosis or the influenza virus. He is now collecting DNA samples from patients from around the world who have had unexpectedly severe courses of COVID-19 or who have had many exposures but have unexpectedly remained free of disease. This approach has the potential to identify host targets that mediate susceptibility or infection in not just the cells that become infected, but also in cells of the immune system that fight infection. Jean-Laurent Casanova 212-327-8000

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