Non-Silica Based Material for High-Performance Liquid Chromatography and Solid Phase Extraction – IP 1717

Supports for reversed phase high-performance liquidchromatography (RP-HPLC) column, normal phase high-performance liquidchromatography (NP-HPLC) column, and hydrophilic interaction liquidchromatography (HILIC) column are silica particles coated with organic ligandsvia silane chemistry. As a result, only a very small portion of the stationaryphase contributes to retention and selectivity. The currently used bondedphases for these chromatography columns suffer from a number of shortcomings:silica particles limit the loading of organic ligands, which leaves manysurface silanol groups unattended on the silica surface, and results inchemical instability, particularly when using basic solvents. FIU inventors have developed sol-gel sorbent orchromatography stationary phase comprising particles of a metal oxide gelcontaining polymeric segments uniformly distributed throughout the metal oxidegel. The chemical incorporation of various organic polymers into the sol-gelhybrid inorganic-organic matrix opens up the possibility of creating hundredsof novel sorbents with unique selectivity. Anne Laure Schmitt Olivier aschmitt@fiu.edu 305-348-5948

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