Noncompetitive Inhibition of MtFBA by 8-Hydroxyquinoline-2- Carboxylic Acid and Derivatives for Tuberculosis Therapeutics

The use of 8-hydroxyquinoline-2-carboxylic acid as an inhibitor against M. tuberculosis class II 1,6-biphosphate aldolase (MtFBA) was found to be a novel and effective alternative to existing antibiotic options. Previous class II FBA inhibitors either lacked specificity or druglike properties to be considered for further drug development. The MtFBA inhibitory and chemical attributes of 8-hydroxyquinoline-2-carboxylic acid and potential derivatives overcome both of these challenges. CeCe Ging techtransfer@du.edu 303-871-4230

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