Novel Chemoenzymatic Synthesis Of Heparin And Heparan Sulfate

Heparin and heparan sulfate (HS) are complex polysaccharides with incredible diversity. They play important roles in many physiological and pathological processes such as regulating cancer growth, blood coagulation, inflammation, assisting viral and bacterial infections, and cell differentiation. Heparin and low molecular weight heparin are the leading therapeutic of choice for use as anticoagulants or antithrombotics today. Researchers at UC Davis have developed a very cost effective and highly efficient method to synthesize heparin and HS oligosaccharide analogs. Maris Apse mpapse@ucdavis.edu 530-754-8718