Novel Targets to Control Reproduction and Their Agricultural and Pharmaceutical Applications

Ovulation is a primary step in oviposition, representing an important target to control insect pests and vectors. The inventors report that the beta adrenergic-like octopamine receptor Octβ2R serves as a key signaling molecule for ovulation and recruits protein kinase A and Ca2+/calmodulin-sensitive kinase II as downstream effectors for this activity. These observations suggest that Octβ2R has distinct signaling capacities in vivo and activate multiple signaling pathways to induce egg laying. The findings reported here narrow the knowledge gap and offerinsight into novel strategies for insect control. Chao Zhang czhang3@utep.edu 915-747-6717

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