PennHFD: A Specialty Corn Feed for Control of Enteritis in Poultry

Penn State University Background
Avian necrotic enteritis (NE) is among the major diseases that affect the gastrointestinal health of broiler chickens. Clinical and subclinical forms of NE negatively impact weight gain, feed conversion ratio, and may result in death. NE is caused by pathogenic strains of Clostridium perfringens (CP), a Gram-positive bacterium. Previously, NE was effectively controlled with in-feed antibiotics. However, the increasing concern for antimicrobial resistance has led to a reduction in the use of antibiotics in animal feed – which, in turn, has been associated with an increased number of NE outbreaks. NE related losses in productivity and the cost of treating and controlling and treating NE is estimated to result in up to $6 billion in losses every year, worldwide.
Technology Overview
Previous studies have shown that flavonoids, compounds naturally found in plants that are known for a wide range of health benefits, can help ameliorate NE in chickens. However, previous supplementation of flavonoid-rich feed resulted in reduced feed consumption and animal performance. To circumvent issues with supplementation, Penn State inventors developed a flavonoid-rich corn variety, named PennHFD, via traditional breeding methods (i.e. with no directed genetic modification). Corn is already a commonly used feed-product for poultry in the United States.
Further Details
In an initial study, the Penn State Inventors demonstrate that chickens challenged with C. perfringens and fed a diet that includes PennHFD, have statistically lower mortality rates, reduced incidence of intestinal lesions, and increased growth performance (as compared to infected chickens receiving diets with non-flavonoid enriched corn).
Interestingly, birds that were not challenged with C. perfringens and fed a diet that included PennHFD, also demonstrate an improved growth performance as compared to non-infected chickens fed a control diet.
Taken together, results demonstrate that the novel high-flavonoid corn variety, PennHFD, may represent an antimicrobial-free, non-GMO alternative for improving health and performance in poultry.
Seeking partner for commercial development.

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