Pericellular Nanonets Collect Cancer Cell Exosomes (Brandeis Ref. 1157 & 1163)

Traditional chemotherapy or molecular therapy has been rendered inadequate as cancer treatments, due to the ever-growing complexity of cancer cells, which leads to cancer drug resistance and metastasis. Moreover, accurate and reliable early cancer detection techniques involving exosome analysis for novel biomarker discovery and identity is lacking, further contributing to the rising mortality rate caused by cancer. Therefore, it is imperative to develop innovative approaches to overcome cancer and drug resistance. The current invention integrates enzymatic transformation and self-assembly of D-peptide derivatives into a novel cancer theranostic technique to improve early cancer detection and cancer treatment. Nanonets of D-peptidic hydrogels selectively form within the pericellular space of cancer cells to simultaneously inhibit target cell survival and entrap cancer cell secretomes, for accurate mapping and discovery of cancer biomarkers and elimination of cancer drug resistance. Rong Zhou zhourong@brandeis.edu 7817368753

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