Pharmaceutical Compositions which Inhibit FKBP52-Mediated Regulation of Androgen Receptor Function and Methods of Using Same (NIH)

MJC13 is a first-in-class drug for targeting the regulation of androgen receptor (AR) by FKBP52. Through binding a recently identified regulatory surface on AR (BF3), MJC13 prevents the FKBP52-receptor complex from dissociating resulting in the retention of AR in the cytoplasm. MJC13 was shown to effectively block AR signaling and AR-dependent cancer cell proliferation in a variety of human prostate cancer cell lines, and preclinical studies demonstrate impressive effects on tumor growth in a prostate cancer xenograft model. Chao Zhang czhang3@utep.edu 915-747-6717